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For example: Methionine exposure was significantly higher with the micellar formulation (up to ~4.6× dose-normalized increase) Other metabolites remained tightly regulated, reflecting the body’s strong homeostatic control These findings highlight that oral glutathione supplementation does not act in isolation—it interacts with sulfur amino acid metabolism and related biochemical systems

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Then, medications can be classified as “very likely”, “probable”, “possible” and “undetermined”, ranking them according to the probability reported in the literature.15,44 Re-exposure to the drug is not recommended as a strategy to confirm the etiological diagnosis of DRESS

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